There are mainly the following clinical reasons for rhinitis after waking up: the first reason is that patients breathe more smoothly when they sleep, and once they wake up, due to the patient’s activities leading to faster breathing frequency, a large amount of allergic substances are inhaled from the air in the nasal cavity, resulting in some changes related to sneezing, itchy nose and runny nose. The second reason is that when the patient is sleeping, due to the lack of activity, once the patient wakes up, it causes the patient to turn over or change, which easily induces allergic substances on the bed sheet and pillowcase to float in the air and be inhaled by the patient’s nasal cavity, resulting in allergic rhinitis. The third reason is that after the patient wakes up from sleep, the nerves in the nasal cavity are in an excited state due to physical activity, and the nasal cavity is more sensitive to airborne substances, resulting in some manifestations of allergic rhinitis. In conclusion, patients who are prone to rhinitis after waking up from sleep generally belong to the allergic group and should be treated actively by applying nasal spray hormones and antihistamine nasal sprays and, if necessary, oral antihistamine drugs and leukotriene receptor antagonist drugs for comprehensive treatment to reduce or prevent the performance of rhinitis after waking up from sleep.