The causes of hypoglycemia in non-diabetic patients include drug factors, disease factors, etc. The causes of hypoglycemia in diabetic patients include exogenous insulin and drugs stimulating endogenous insulin secretion. 1. Non-diabetic patients: Drugs are the most common cause of hypoglycemia, including quinolones, pentamidine, quinine, beta-blockers, angiotensin-converting enzyme inhibitors and insulin-like growth factor-1. Disease factors include liver failure, renal failure, heart failure, sepsis or nutritional deficiencies, as well as β-cell tumors, β-cell functional diseases, insulin autoimmune hypoglycemia, etc. 2. Diabetic patients: diabetic patients use exogenous insulin and drugs that stimulate endogenous insulin secretion (such as pro-insulin secretion agents: glibenclamide, gliclazide, glipizide, glimepiride, repaglinide, nateglinide) will stimulate increased glucose utilization, and if used improperly can cause hypoglycemia, or even the occurrence of severe or fatal hypoglycemia. Patients with unexplained recurrent episodes of hypoglycemia are advised to seek prompt medical attention to have the cause clarified and treated by a medical professional.