After the recurrence of colon cancer, systemic manifestations such as pain, fatigue and local manifestations such as mass and dysfunction at the site of recurrence may appear, but the statement of 6 signs is a little bit absolute. Colon cancer is a malignant tumor caused by heredity, gene mutation and other factors. Due to the high degree of malignancy, recurrence often occurs after surgery, such as in-situ recurrence, liver metastasis and so on. 1. Systemic manifestations: there may be systemic symptoms such as fatigue and fever; 2. Local manifestations: there are different manifestations according to the different sites of recurrence, such as in situ recurrence with changes in bowel habit and character; liver metastasis with symptoms such as discomfort in the liver area, nausea and vomiting. Lumps can also be found in the recurrence site, accompanied by pain. At this time, radiotherapy, targeted therapy and other methods of treatment, in addition to regular follow-up as prescribed by the doctor, can be timely detection of recurrence, so as to timely treatment.