When the blisters on the soles of the feet are not itchy or painful, the causes of the blisters can be divided into non-disease factors and disease factors according to the characteristics of the blisters and accompanying symptoms, and non-disease factors can be alleviated by proper rest and changing walking posture, while disease factors need to be treated with medication according to medical advice. First, non-disease factors: such as improper walking posture, long-term wearing of shoes that do not fit the foot or long standing, walking for too long, etc., can lead to blisters on the soles of the feet due to excessive friction. And, the living environment is hot, sweating more, etc. may also cause blisters on the soles of the feet. These are generally simple blisters, sometimes appearing as blood blisters, and are usually not accompanied by other uncomfortable symptoms. Treatment can be used to extract the fluid in the blisters with a syringe, while trying to avoid excessive friction and other factors that cause trauma and cause infection. Disease factors: 1. Blister-type tinea pedis: If there are dense small blisters on the soles of the feet, sometimes accompanied by peeling skin, they may be caused by a fungal infection and belong to blister-type tinea pedis. If the test result is positive, antifungal drugs such as ketoconazole and miconazole can be applied as prescribed by the doctor. 2. eczema: If the foot blisters are accompanied by red papules, they may also be caused by eczema, and the treatment requires anti-inflammatory and anti-allergic drugs such as loratadine and cetirizine. 3. palmoplantar pustulosis: If the blisters are distributed in turbid patches and surrounded by obvious skin If the blisters are cloudy and flaky, with obvious skin peeling around them, symmetrically distributed on the palms and feet, they may be palmoplantar pustulosis, which can be treated with topical glucocorticoids, such as mometasone furoate cream and dinaide cream, etc.; 4. Need to go to the hospital for pathological testing, after a clear diagnosis can be systemic systemic treatment, such as the application of glucocorticoid drugs such as prednisolone tablets, as well as cyclosporine and other immunosuppressant drugs as prescribed by the doctor.