Major triple yang is categorized into chronic hepatitis B and acute hepatitis B. There is a possibility of recurrence of its surface antigen turning negative. After anti-hepatitis B virus treatment, patients with chronic hepatitis B with triple positive test show negative hepatitis B surface antigen, but this does not mean that the hepatitis B virus has been completely eliminated, the patient’s liver cells may still have a very low level of viral replication, which is generally undetectable by test reagents, and when the anti-viral drugs are discontinued, the virus may replicate in large quantities again, thus leading to relapse. Patients with acute hepatitis B who are triple positive, although the virus is cleared, but the body does not have time to produce surface antibodies to hepatitis B, so there is no immunity to hepatitis B. When contacted with the hepatitis B virus again, there is still a possibility of being infected by hepatitis B, so there will be a relapse. After the surface antigen has been turned negative, patients with triple III positive should follow the doctor’s instructions and should not stop taking medication without authorization, but should be treated under the guidance of a professional doctor.