High bilirubin is often associated with hemolytic diseases, liver diseases, biliary tract diseases, etc. Its harm is mainly related to the aforementioned diseases and their complications, such as jaundice, severe anemia, infections and so on. 1. Hemolytic diseases: Hemolytic diseases such as hemolytic anemia, blood group incompatibility and drug hemolysis will cause bilirubin due to the damage of red blood cell rupture, and high bilirubin will be found through examination. If not treated in time, severe anemia and hemolytic jaundice may occur. 2. Liver diseases: for example, hepatitis, fatty liver, cirrhosis and so on. These diseases may cause high bilirubin. If it is only a mild liver disease, it is not harmful, but if it is not treated properly, it may progress to a more serious stage, and there is a risk of cancer. 3. Biliary tract diseases: for example, cholangitis, bile duct stones, gallbladder stones, etc. These diseases will lead to high bilirubin, and if the bile can not be discharged out of the body smoothly, it will easily lead to obstructive jaundice, or even septic cholangitis. High bilirubin can also be caused by physiological reasons such as excessive alcohol consumption and overeating, which can be alleviated by improving poor lifestyle. If it is caused by pathological factors, you should consult a doctor in a timely manner, under the guidance of a professional physician to avoid aggravating or delaying the condition.