Calf cramps while sleeping may be caused by physiological reasons such as fatigue, or may be caused by pathological reasons such as electrolyte deficiency, lumbar spine disease, neurological disease, etc. Calf cramps while sleeping may be caused by physiological reasons such as fatigue, or may be caused by physiological reasons such as cold. 1. Excessive fatigue: often due to excessive fatigue of the calf or cold, cold and other physiological causes of local metabolite accumulation, muscle contraction and relaxation is difficult to coordinate, in the sleep of the calf cramps can occur. 2. Electrolyte deficiency: It is mainly caused by calcium ion deficiency which leads to calf muscle contraction disorder, and calf spasm and cramp can occur during sleep. 3. Lumbar spine diseases: such as lumbar disc herniation, lumbar spinal stenosis, lumbar spine tumors and other diseases, the discs stimulate the nerves innervating the lower limbs when you turn over in your sleep, and the patients may have calf cramps. 4. Neurological diseases: such as transient cerebral ischemia and other central nervous system diseases, diabetic peripheral neuropathy, can cause patients to sleep with symptoms of calf cramps. Calf cramps while sleeping may also have other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause, give targeted treatment or treatment.