Drumheller’s disease is a multisystem developmental abnormality in which the patient often possesses pathogenic mutations in multiple genes. Also known as Delange syndrome, it is a genetically heterogeneous multisystem developmental disorder characterized by growth disorders, multiple organ developmental abnormalities, and neurocognitive dysfunction. Patients usually have severe intellectual disability problems, characterized by microcephaly, feeding difficulties, and malformations, and many individuals show a tendency toward autism and self-mutilation. Prenatal diagnosis of high-risk pregnancies is necessary to avoid the development of Dranje syndrome, often requiring Down’s syndrome screening and color Doppler ultrasound during pregnancy. In order to reduce the incidence of problematic babies and to start with the idea of having a healthy child, it is advisable for pregnant women to ensure adequate nutritional intake requirements, get enough sleep, and try to avoid electromagnetic radiation, heavy medication, exposure to chemicals, and viral infections during pregnancy.