I. Gastrointestinal drugs: cimetidine, ranitidine, nizatidine, they can cause sexual dysfunction, and young men who take these drugs for a long time can develop impotence, loss of libido and breast development. Second, psychostimulants and narcotics: cocaine, heroin, alcohol, etc. Alcohol can increase sexual desire, but it can affect erectile function and reduce the hardness of the penis erection. Third, cardiovascular drugs: anti-hypertensive drugs, the most commonly caused male sexual dysfunction are mainly diuretics and beta-blockers. Diuretics commonly used in the treatment of hypertension: 1, thiazide diuretics, mainly dihydroketuria; 2, spironolactone, also known as androstenedione, which has an anti-androgenic effect, inhibiting the biosynthesis of androgens, causing hypersexuality, breast development and erectile dysfunction in men. In addition to hypertension drugs, anti-arrhythmic drugs amiodarone, anti-heart failure drugs digoxin, etc. can also cause male sexual dysfunction. Four, anti-tumor drugs: cyclophosphamide, nitrogen mustard, vincristine, cytarabine and other drugs can cause male erectile dysfunction or sperm deficiency. V. Prostate drugs: Drugs for prostate enlargement such as 5-alpha reductase inhibitors can also have side effects such as erectile dysfunction and reduced ejaculate volume. In addition, drugs commonly used to treat prostate cancer such as anti-androgen drugs can affect libido, penile erection and ejaculation by affecting the secretion of androgens. The most common depressants are promethazine, amitriptyline, chlorpromazine, new selective 5-hydroxytryptamine reuptake inhibitors, etc., which can cause erectile dysfunction, abnormal ejaculation and lack of libido.