The famous American superstar Michael Jackson, who died not long ago, was proved by the police to have died from the illegal use of high doses of the narcotic drug Propofol. So, what kind of drug is Propofol? What role did it play in Jackson’s death? Propofol, also known as Depo-Provera, is the ideal hypnotic intravenous general anesthetic for patients who fall asleep 15 seconds to 30 seconds after routine injection, with a rapid onset and smooth, short duration, 5 minutes to 10 minutes for patients to wake up, and complete awakening, no excitement. However, it should be especially reminded that propofol has a strong cardiovascular and respiratory depressant effect and should only be used by qualified anesthesiologists under the guarantee of resuscitation and rescue equipment. It is widely used for analgesia for various minor procedures or traumatic examinations such as outpatient painless gastroscopy, painless colonoscopy, painless abortion, as well as for induction and maintenance of anesthesia for major surgery. Michael? After the announcement of Jackson’s death, many people have misunderstood the anesthetics and even refused to use propofol. There is no need to worry too much about this, as propofol will not cause major problems as long as it is used correctly. However, patients who need to have painless examinations should go to a large qualified hospital that has the necessary conditions to ensure safety. Only anesthesiologists are qualified to use propofol. Propofol is a milky white liquid, often called “milk” by anesthesiologists. As a strong sedative, it is usually used for general anesthesia, but also for small operations or examinations of short duration, such as painless gastroscopy or abortion in major hospitals, where propofol is often used. It is different from OTC type drugs or general prescription drugs, and should not be held in the hands of the general public. Even in hospitals, it is not normally used by doctors. It is important to emphasize that 25 mg of propofol is not lethal to a normal person. At best, it can make you drowsy, sleepy and yawn a lot. For example, in the operating room, propofol is used as an anesthetic induction drug, usually 100-200 mg for adults. such a large dose of propofol does not pose an absolute threat to you. This is due to the fact that the operating room provides the patient with excellent monitoring equipment and respiratory support, with the anesthesiologist behind the scenes. Propofol is a good drug, but when pushed into a blood vessel it can cause pain, medically known as “propofol injection pain”. This pain is similar to burning. Although the exact mechanism is unclear, the injection of lidocaine can relieve this pain. Lidocaine is a local anesthetic that is used for local surgery or tooth extraction. However, if overdosed or injected too quickly, it can cause a drop in blood pressure or cardiac arrest. Therefore, the safe application of propofol can not be monitored, that is, heart rate, blood pressure, oxygen saturation, etc. need to be monitored, and it is not known whether Jackson has a monitor at home. The sedative effect of propofol is fast-acting, usually within 30 seconds, and can put people to sleep. For Jackson, who suffered from insomnia and no good solution (there are reports that Jackson had insomnia for several years, even up to ten years), propofol is too suitable. But without a dedicated doctor and monitor present, this is tantamount to playing with fire, so it cannot be used to treat insomnia. Propofol can cause temporary respiratory depression, circulatory depression, and its drug insert clearly states that propofol injection should be used with caution in patients with cardiac, respiratory, renal or hepatic impairment or in patients with reduced and debilitated circulating blood volume. Only trained anesthesiologists are qualified to use propofol.