Quadruple therapy for the treatment of Helicobacter pylori is mainly to take a proton pump inhibitor, a bismuth agent and two antibiotic drugs in combination. 1. Proton pump inhibitors: such as omeprazole, pantoprazole, lansoprazole, rabeprazole, etc., the main function is to inhibit the secretion of gastric acid, to avoid further stimulation of the gastric mucosa. 2. Bismuth: such as colloidal bismuth pectin, bismuth potassium citrate, etc., can protect the gastrointestinal mucosa and promote mucosal repair. 3. Antibiotic drugs: for example, metronidazole, amoxicillin, clarithromycin, etc. The main function is to kill Helicobacter pylori. Helicobacter pylori in taking quadruple therapy, the course of treatment is generally 10-14 days, the end of the treatment is discontinued for more than four weeks, you need to go to the hospital to review, check the effect of treatment. Quadruple therapy must be guided by a doctor to use drugs, the patient can not be arbitrarily used on their own.