When there is pus at the site of vaccination, there are two cases to be considered first, one is BCG vaccine after vaccination against tuberculosis and the other is other vaccines, and the two cases are handled differently. The BCG vaccine usually causes redness and swelling at the vaccination site about 3 weeks after the vaccination, and gradually small white pustules are formed, and pus will be discharged after the pustules break down, and the crust will heal after 1-2 weeks. If there are swollen lymph nodes near the vaccination site, this is a normal reaction and will subside on its own. If there are pustules or ulcers locally after BCG vaccination, there is no need to rub or bandage them, but keep the area clean and dry, do not wear clothes too tightly, if there is pus outflow, use sterile gauze or cotton to gently wipe clean, avoid squeezing, and wait for 2-3 months for natural healing and scabbing. If there is pus at the site of injection of other vaccines, it should be treated promptly. If there is more pus, the pus can be extracted with a syringe under the operation of a doctor to promote healing. At the same time, maintain local hygiene and disinfect the site with iodophor, and apply mupirocin ointment locally after disinfection. If the symptoms are not relieved, the occurrence of local infection is suspected, and prompt surgical examination at a hospital is required to take debridement treatment to avoid aggravation of the condition. In addition, after vaccination, you should stay at the vaccination site for 15-30 minutes and leave after no reaction. Avoid touching water at the vaccination site for 24 hours, maintain local hygiene, change clothes regularly, and prohibit scratching the vaccination site with your hands to avoid local infection. Drink more water, take more rest, do not do strenuous exercise, and go to the hospital for examination and treatment if there is fever in the body.