Urine occult blood 4 +, urine protein 3 + to consider the possible existence of glomerulonephritis, vasculitis, nephrotic syndrome and other diseases related to the problem. 1. Glomerulonephritis: patients with glomerulonephritis can have urinary occult blood and a large amount of urine protein, this situation can be combined with the patient’s clinical symptoms and follow the doctor’s instructions for renal puncture to clarify the pathology of the diagnosis, after the diagnosis of the need to choose hormones and/or immunosuppressants such as prednisone, cyclosporine and other drugs treatment. 2. Vasculitis: Kidney injury caused by vasculitis can also occur urinary occult blood and urinary protein, so we need to follow the doctor’s instructions to clarify the location of vasculitis, symptomatic treatment. 3. Nephrotic syndrome: when patients have nephrotic syndrome, it will lead to hematuria, urinary protein, hyperlipidemia, hypoproteinemia and other problems, generally need to follow the doctor’s instructions to determine the pathology of nephroptosis, and take reasonable treatment plan. In addition, pyelonephritis, coagulation dysfunction and other diseases can also appear urinary occult blood 4 +, urine protein 3 +. Urine occult blood 4+, urine protein 3+ may have other causes, it is recommended to consult a regular hospital, under the guidance of nephrologist for further diagnosis and treatment, do not self-medication.