Small blisters on the seam of the toes (i.e., “blisters”) accompanied by itching, may be tinea pedis, eczema, hand, foot and mouth disease and other diseases. 1. Tinea pedis: common in blisters scaly tinea pedis, mainly by the red trichophyton, trichophyton, gypsum-like microsporidium and flocculent epidermis and other fungal infections caused by the skin disease. The early lesions are pinpoint-sized blisters with thick walls that are not easy to break, and can be accompanied by obvious itching. 2. Eczema: a multifactorial inflammatory disease of the superficial dermis and epidermis, common causes include contact, inhalation or ingestion of allergens or chronic infections, etc., blisters can appear in the cracks of the feet, accompanied by itching. 3. Hand, foot and mouth disease: common in children, with coxsackievirus A16 and enterovirus 71 caused by the most common infections. Often in the oral mucosa, hands, feet, buttocks and other parts of the erythema, herpes, etc., so can appear in the foot cracks small blisters and with itching, serious cases may also be accompanied by other systemic abnormalities. When small blisters with itching appear on the cracks of the toes, it is recommended to consult a doctor in time for relevant examinations, to clarify the cause under the guidance of the doctor, and to carry out individualized treatment.