Anemia may cause leg swelling. Anemia is a clinical syndrome that occurs when the volume of red blood cells in the peripheral blood is lower than normal. Anemia is a symptom that is associated with a variety of diseases. But regardless of the disease, if the anemia is longer and more severe, it will cause changes in heart function, often inducing anemic heart disease and leading to the patient’s heart decompensation, when edema of both lower limbs will occur. Therefore, some patients with anemia, especially those with severe anemia, can have swollen legs. Also, because anemia can be seen in a variety of diseases, such as renal anemia, which is also a common type of anemia, patients with renal anemia are more likely to have leg swelling due to a decrease in erythropoietin concentration caused by renal failure. Kidney injury is also prone to leg swelling. Anemia is a symptom that may cause leg swelling.