Panic and shortness of breath in the afternoon may be due to endocrine disorders, menopause and infectious diseases. 1. Endocrine metabolic and endocrine disorders such as hyperthyroidism and hyperadrenocorticism may cause cardiac arrhythmia, which may lead to panic attacks and shortness of breath in the afternoon. 2. If you are a woman, during menopause, it may cause an imbalance in the secretion of estrogen and progesterone, and dysfunction of the endocrine system, which may lead to the symptoms of panic attacks and shortness of breath in the afternoon. 3. If you suffer from infectious diseases such as tuberculosis, dermatomyositis, rheumatoid arthritis, etc., especially in the afternoon, you will have an elevated body temperature, and an elevated body temperature may cause panic and shortness of breath. When panic and shortness of breath are evident, it is necessary to actively consult a doctor and follow the doctor’s instructions for reasonable treatment.