Antihypertensive drugs and Roaccutane capsules are best not taken together. There are more types of antihypertensive drugs, including hydrochlorothiazide, nifedipine, captopril, etc., of which nifedipine is mainly eliminated through the cytochrome oxidase system. Roxithromycin will inhibit the cytochrome oxidase system in the body, causing the metabolism and clearance of nifedipine to slow down, causing the blood concentration of nifedipine to increase, which is prone to cause adverse drug reactions and side effects. Therefore, it is not recommended to take antihypertensive drugs and Roaccutane capsules together. Antihypertensive drugs may cause hypotension, edema, heart failure and other adverse reactions, allergy to antihypertensive drugs and severe heart failure patients prohibited antihypertensive drugs. Taking Roxithromycin capsules may cause adverse reactions such as nausea, vomiting, skin itching, liver function abnormalities, allergy, severe liver and kidney failure patients are prohibited Roxithromycin. After taking antihypertensive drugs and roxithromycin capsules appear physical discomfort as soon as possible to seek medical treatment, timely treatment, to avoid further progress.