Colonic mucosal bulging may be related to colitis, colon polyps, gastrointestinal mesenchymal tumors and other lesions, which need to be treated medically and surgically according to the cause. 1. Colitis: For colonic mucosal bulging caused by colitis, in addition to adjusting diet and lifestyle habits, it is also necessary to use amino acid salicylic acid preparations such as mesalazine or antibiotics such as metronidazole and other medications according to the cause and lesions. 2. Colon polyps: for colon polyps caused by the colon mucosal bulge, often endoscopic resection treatment, the specific way to be based on the size of the polyp, the nature of the pathology, the number of polyps, as well as complications and other factors to decide. 3. Gastrointestinal mesenchymal tumors: for gastrointestinal mesenchymal tumors caused by colonic mucosal bulge, the first choice of treatment is also endoscopic treatment, if the volume is large and other factors can not be treated endoscopically need to be surgical resection and so on. If there is a colon mucosal bulge, it is recommended to go to the hospital in time, by the doctor according to the specific conditions of the individualized diagnosis and treatment plan, so as not to delay the condition.