- Decreased appetite, sudden onset of acid reflux, heartburn, epigastric pain, nausea, vomiting, vomiting of blood, black stools, jaundice, progressive wasting, and weight loss.
- Presentation of intestinal obstruction, including abdominal distension, cessation of bowel movements, and in severe cases, abdominal pain, nausea and vomiting.
- The presence of ascites may indicate peritoneal metastasis. A small amount of ascites can usually be detected only by imaging (e.g., CT, ultrasound), and moderate to large amounts of ascites may present with abdominal distention, abdominal bulging, and in severe cases, dyspnea and umbilical hernia.
- Cough, shortness of breath, hemoptysis, and chest pain may indicate pulmonary metastases.
- Sudden onset of hemiparesis, convulsions or headache and blurred vision on one side of the body may be a brain metastasis.
- The presence of symptoms such as bone pain and anemia may lead the doctor to consider the possibility of bone metastasis.
- Enlarged lymph nodes on the left supraclavicular region and enlarged lymph nodes in superficial areas of the body may be distant lymph node metastases.