Heterogeneous hyperplasia generally refers to the occurrence of heterogeneous proliferative changes in the epithelium of the gastric mucosa. The so-called heterogeneous hyperplasia, also known as atypical hyperplasia, is a chronic atrophic gastritis in which intestinal metaplasia occurs during the development of gastric mucosal atrophy. The gastric epithelium or the intestinal epithelium of the metaplasia undergoes abnormal development during the regeneration process, which can result in heteroplasia. The heterogeneous hyperplasia is a precancerous lesion of gastric cancer, especially if there is severe atypical hyperplasia, it can be called early gastric cancer. If heterogeneous hyperplasia occurs, it is important to pay great attention to it, and if necessary, it is necessary to cooperate with doctors for preventive surgery.