I. Prevention and control objectives.
1.Correct hyperuricemia
2. Rapidly terminate acute arthritis attacks
3.Prevent recurrence
4, prevention and control of uric acid stones and kidney function damage
Second, acute gout.
1.Colchicine
It has anti-inflammatory and pain-relieving effects, with quick results.
The drug is toxic, adverse reactions include nausea, vomiting, diarrhea, liver damage, bone marrow suppression and hair loss.
Colchicine is discontinued when one of three criteria is met.
(1) Significant improvement in pain or inflammation.
(2) Severe gastrointestinal reactions.
(3) Total amount reaches 6.0mg under normal liver and kidney function.
2.Anti-inflammatory and analgesic drugs
Anti-inflammatory and analgesic effects
Commonly used drugs: Fotalin, nabumetone, fenpropathrin
Side effects: gastrointestinal tract, liver damage, bone marrow suppression, kidney damage, drug allergy
3.Hormone
Anti-inflammatory and analgesic effects, not routinely used
Chronic gout, hyperuricemia.
1.Promote uric acid excretion drugs: Ligarixian
Used for those with elevated blood uric acid, good kidney function and no urinary tract stones.
Not to be taken in the acute attack period.
Side effects: gastrointestinal reactions, diarrhea, conjunctivitis, rash, renal colic and acute arthritis attack may occur.
2.Uric acid synthesis inhibitor: allopurinol
Suitable for people with excessive uric acid production, moderate to severe renal hypofunction, and urinary stones.
Side effects: Gastrointestinal reactions, skin rash, fever, liver damage, reduced white blood cells, etc. Occasionally, exfoliative dermatitis is seen.
IV. Other
1. Drink more water to facilitate uric acid excretion.
2. Oral sodium bicarbonate can be taken to keep the urine alkaline and prevent stone formation.
V. Attention.
1. Why uric acid-lowering drugs need to be taken for a long time
Every person has uric acid in his body, and the blood uric acid in gout patients is higher than normal. Lowering uric acid is a long-term task, and the value of uric acid found by patients is the value of uric acid in the blood, not the concentration of uric acid crystals in the joint space, because a large amount of uric acid will sink in the joint space after forming crystals. The result of stopping the medication after a period of time is that the blood uric acid rises again very quickly due to the precipitation of crystals. Therefore, it is necessary to take the drug for a long time to make the crystals in the joint space completely excluded.
2.Is it possible to take a large amount of drugs to lower uric acid?
The answer is no. When the patient’s blood uric acid suddenly decreases, the gout stone on the joint surface dissolves and crystals can be precipitated, causing a rapid increase in the blood uric acid value, resulting in a gout attack.
3, gout patients are often combined with hypertension
The choice of antihypertensive drugs is cautious with compound antihypertensive drugs containing diuretics, Shoubisan, antihypertensive zero, etc.