Hepatitis B triple yang has been off the medication for three months, whether you need to use medication needs to be judged by liver function, the number of hepatitis B virus replication, liver ultrasound and so on to determine. 1. Liver function: liver function mainly refers to alanine aminotransferase and azelaic aminotransferase, the elevation of both of them may indicate the inflammatory reaction of liver, clinically obvious elevation, especially more than twice of the normal high value suggests that the inflammatory reaction of liver is serious and liver cells have obvious damage, and it can be treated with medicines to protect the liver (e.g. polyenphosphatidylcholine, etc.) according to the doctor’s instruction. 2. Hepatitis B virus replication number: Hepatitis B virus replication number is obviously increased, more than three times of 10, when there is liver function damage, it is often necessary to take oral antiviral drugs (such as entecavir, etc.), but of course, it is also necessary to combine with the ultrasound of the liver, the family history of a comprehensive judgment. 3. Liver ultrasound: Liver ultrasound suggests significant increase in liver stiffness, especially over 17.5, to assess whether there is cirrhosis of the liver, and when cirrhosis occurs, long-term treatment with antiviral drugs is needed. In the clinical treatment of hepatitis B antiviral drugs, it is not advisable to stop using the drugs arbitrarily, otherwise relapse may occur, and it is recommended to review regularly and consult the department of infection of regular hospitals.