Coughing up sputum with blood may be due to the existence of gingivitis, bronchial dilatation, lung cancer and other diseases, which can be solved by gargling with compound boric acid solution, perfecting the imaging examination, using cephalosporin, radiotherapy and other methods. 1. Gingivitis: patients with gingivitis often have symptoms of bleeding gums, coughing up sputum may carry gum blood when sputum passes through the oral cavity, coughing up is regarded as sputum with blood, generally can be prescribed by the doctor with compound boric acid solution and other medications such as gargling treatment. 2. Bronchial dilatation: coughing up sputum, blood in sputum or even hemoptysis are common symptoms, generally need X-ray, chest CT, bronchoscopy and other examinations to confirm the diagnosis, there is evidence of bacterial infection can be used ampicillin/sulbactam, cephradine and other anti-infective treatments, nebulized inhalation of saline to promote the expulsion of sputum and so on. 3. Lung cancer: Diagnosis can be confirmed by sputum exfoliative cytology, bronchoscopy, CT, etc. Blood in sputum is mostly seen in central lung cancer, which usually requires comprehensive treatment mainly by surgery. Coughing sputum with blood may also have other reasons, so one should go to the hospital in time and find out the reasons under the doctor’s guidance, so as to avoid delaying the condition.