Pain in the second knuckle of the right middle finger is alert to osteoarthritis, tendon sheath cysts, traumatic lesions, bone tumors and other lesions. 1. Osteoarthritis: generally occurs in elderly patients or patients with previous trauma to the middle finger, the pain is generally aggravated by hand exertion and alleviated by rest, and can be clearly diagnosed by X-ray examination. 2. Tendon sheath cysts: generally in the second joint of the middle finger can be touched relatively small such as soybean-sized lumps, the lumps are generally movable, obvious pressure pain, clear boundaries. 3. Traumatic factors: such as joint capsule or ligament injury, usually with a history of trauma. 4. Bone tumor: such as endogenous chondrosarcoma, etc., which can be clearly diagnosed by X-ray film and MRI. There are many reasons for the pain in the second joint of the right middle finger, if accompanied by redness, swelling and elevated skin temperature, etc. also need to be alert to gout and septic arthritis and other lesions, it is recommended to go to the hospital in a timely manner.