Hodgkin’s lymphoma, also known as Hodgkin’s disease, is a distinct type of lymphoma and one of the most common malignancies among young adults. Hemophagocytic syndromes are a group of inflammatory overreaction syndromes that result from primary or secondary immune abnormalities. Hodgkin’s lymphoma can be associated with hemophagocytic syndrome, which is very aggressive and requires prompt treatment. 1. Hodgkin’s lymphoma is a unique type of lymphoma, which is a malignant tumor, and it is prevalent in young people, and it firstly occurs in lymph nodes, which is common in cervical lymph nodes and supraclavicular lymph nodes, and then spreads to other lymph nodes, and in late stage, it can invade blood vessels, and involve spleen, liver, bone marrow and gastrointestinal tract, and so on, and the typical symptoms of patients are lymphatic enlargement, and the local compression symptom is obvious. 2. Hemophagocytic syndrome is an inflammatory overreaction syndrome triggered by immune abnormality. Common triggering factors of the disease include infection, tumor, autoimmune disease, etc. Common symptoms of the patients include fever, enlarged spleen, hepatitis, and coagulation dysfunction, etc. If the patient is diagnosed with Hodgkin’s disease, the patient may be diagnosed with Hodgkin’s disease. If patients are diagnosed with Hodgkin’s lymphoma or phagocytic syndrome, they should receive early treatment under the guidance of a physician, with medications such as etoposide and cyclophosphamide, so as not to delay their condition.