Café-au-lait spots are brown patches that can be found at birth or soon after birth, mostly on the face and trunk, with different shapes and clear boundaries, and increase in size with age; most of the café-au-lait spots are simple pigmentation changes, but this disease may also be one of the early symptoms of some serious hereditary diseases. Café au lait belongs to a kind of hyperpigmented skin disease, the specific pathogenesis is still unclear, most of them are seen in normal people, and their occurrence has little relation with ultraviolet radiation such as sun exposure, and they can usually appear at birth or in infancy. Café au lait can also be one of the manifestations of a variety of systemic hereditary diseases, such as neurofibromatosis, mottled lesions, multiple melanoma syndrome, leopard spot syndrome, ataxia capillary dilatation disease and so on. It is recommended that patients go to regular hospitals for consultation to clarify the cause of the disease, and patients with cosmetic concerns can under the guidance of professional doctors for laser treatment.