Headache after shingles medication may be an adverse reaction to the drug, it is recommended to stop the drug or change to other drugs, if the headache symptoms are serious, oral painkillers for relief. Herpes zoster is a disease caused by varicella zoster virus infection, the main symptom is pain in the lesion area, followed by papules or blisters on the surface of the skin. Herpes zoster patients oral antiviral drugs may have adverse reactions, such as headache, mild symptoms, generally stop the drug after the headache symptoms will disappear on their own, and then go to the regular hospital to consult the doctor to adjust the medication as prescribed, if the patient’s headache symptoms are serious, it is recommended that under the guidance of the doctor to take oral pain relievers, such as acetaminophen tablets, etc. for relief. Shingles patients with headaches after the use of medication, should immediately stop using medication, and promptly go to the hospital for treatment.