Itching and pain after vaginal medication may be caused by improper operation, drug irritation or allergy, or vaginal foreign body. 1. Improper operation: In the process of vaginal medication, it is generally required to put the drug in the deep part of the vagina, and if the drug is applied with greater force, it may cause damage to the mucous membrane of the vagina, which in turn may cause vaginal itchy and painful sensation. It is generally recommended to use the squatting position or semi-squatting position, lubricate the vagina and then slowly insert the drug into the vagina. 2. Drug stimulation or allergy: most of the vaginal drugs are suppositories or gels, some of the ingredients in the drug may cause irritation to the vaginal mucosa, or allergic reaction after the drug, so there will be discomfort after the drug. If the discomfort is particularly strong, it is recommended to remove the drug in time and explain the reason to the doctor, consider replacing the drug, and if necessary, follow the doctor’s instructions to take oral cetirizine hydrochloride tablets and other anti-allergy treatment. 3. Vaginal foreign body: Vaginal medication requires the use of gloves or special equipment, therefore, may lead to gloves and other foreign objects left in the vagina, and then itchy and painful feeling. It is recommended to check the integrity of the gloves and other items after the medication is administered. If it is considered that there is a foreign body left behind, it is recommended to seek medical attention in time to remove the foreign body. If the itchy and painful symptom persists after vaginal medication is administered, the patient should seek medical attention to treat the symptom under the guidance of a doctor.