The vaccination requirements for HPV (human papillomavirus) vaccination depend on the vaccine. In the case of the nine-valent vaccine, the age of 16-26 years old, bivalent and quadrivalent vaccination age is 9-45 years old, vaccination is best to avoid menstruation, breastfeeding; pregnant women and the vaccine components of the population have a serious allergy prohibited, the existence of acute febrile people should be delayed in the vaccination and so on. HPV vaccine belongs to the second type of protein vaccine. Usually, HPV vaccine is divided into bivalent, quadrivalent and nine-valent, and the age group for different types of vaccination is different, the age for nine-valent vaccination is 16-26 years old, and the age for bivalent and quadrivalent vaccination is 9-45 years old. Usually, in addition to the vaccine suitable for different ages, need to pay attention to pregnancy and lactation to avoid vaccination, menstruation is not a contraindication to vaccination but generally can be avoided as much as possible is best, so as not to aggravate the discomfort of menstruation. Usually, if the vaccinee exists acute febrile diseases should wait until the disease is controlled before vaccination; coagulation mechanism disorders and other diseases vaccination need to be careful, should consult a physician before vaccination; HPV vaccine in the drug components of severe allergies should be prohibited. HPV vaccine is mainly used to prevent human papillomavirus infection, so as not to cause cervical cancer, penile cancer, oral cancer, anal cancer, warts and other diseases due to continuous infection of the virus. For women who are sexually active, pregnancy needs to be ruled out before receiving this vaccine. Therefore, for those who intend to receive the HPV vaccine, it is necessary to know the corresponding contraindications and precautions beforehand, and to be vaccinated under the guidance of a physician.