The efficacy of medication in the treatment of premature ejaculation varies greatly depending on the cause of the disease, the severity of the disease, and the physical condition of the individual, so it is not possible to say which medication is good or bad. Drug treatment is currently one of the main treatment measures for men with premature ejaculation, clinical local anesthetic, 5-hydroxytryptamine reuptake inhibitors and other drugs are most commonly used. The therapeutic effect of the medication will be affected by the type of medication used, the individual’s physical condition, compliance with the medication, the severity of the disease and other factors, the specific efficacy of the treatment varies from person to person. It should be noted that, in addition to drug therapy, cognitive behavioral therapy and other psychological treatments are also the main treatment for premature ejaculation, and the combined use of various therapies can often achieve better treatment results than a single therapy. Therefore, it is impossible to predict the effectiveness of medication in treating premature ejaculation in men. People diagnosed with premature ejaculation must choose and adjust the treatment plan under the guidance of a doctor according to the actual situation of the individual, and must not dispose of it on their own or blindly use medication, so as to avoid inappropriate intervention and adverse consequences.