Non-atrophic gastritis can take omeprazole. Non-atrophic gastritis is a kind of chronic inflammation of gastric mucosa caused by factors such as Helicobacter pylori infection or long-term alcohol abuse, and the surface of gastric mucosa may appear erosion, but there is no atrophy, septic and other lesions. Patients may manifest abdominal pain and bloating, postprandial fullness, acid regurgitation and belching, nausea, loss of appetite and so on. Patients with non-atrophic gastritis usually suffer from acid reflux, belching, heartburn and other symptoms due to excessive gastric acid secretion, and most of them need acid-suppressing treatment, and commonly used acid-suppressing drugs mainly include proton pump inhibitors and H2 receptor antagonists. Omeprazole is a proton pump inhibitor, which can specifically inhibit the secretion of gastric acid by gastric mucosal wall cells and reduce the concentration of gastric acid in the stomach, with a strong and long-lasting effect. It is commonly used in clinical practice for the treatment of gastric ulcers, duodenal ulcers, stress ulcers, reflux esophagitis, and Drewe-Ayre syndrome and other disorders of excessive gastric acid secretion. Therefore patients with non-atrophic gastritis can take omeprazole when they experience excessive stomach acid secretion. However, adverse reactions such as diarrhea, headache, nausea, abdominal pain, flatulence and constipation may occur when Omeprazole is taken. It should be used with caution in the elderly, children, pregnant and lactating women, and those with hepatic or renal insufficiency, and is contraindicated in those who are allergic to the product, those with severe renal insufficiency, and infants and young children. Patients with non-atrophic gastritis are advised to seek prompt medical attention and professional treatment under the guidance of a doctor.