Microinvasive adenocarcinoma usually belongs to early stage cancer and can be treated with surgery, targeted therapy, radiotherapy, etc. However, the specific treatment plan needs to be decided according to the stage and severity of the patient’s condition. Generally, microinvasive adenocarcinoma is in early stage without lymph node and distant metastasis, and it is possible to achieve cure with surgical treatment. In a small number of patients, microinvasive adenocarcinoma may have already led to larger damage or distant metastasis, and this part of patients belongs to the middle and advanced stage of microinvasive adenocarcinoma. This requires comprehensive treatment such as surgery, targeted therapy, radiotherapy and chemotherapy according to the patient’s condition and stage to prolong the patient’s life. Patients with clear diagnosis of microinvasive adenocarcinoma must actively cooperate with doctors for treatment, because the probability of cure is high with surgical treatment plus radiotherapy and targeted therapy.