Skin rash after immunotherapy may be drug rash, depending on the extent of the rash, medication can be taken to relieve symptoms, cetirizine, dexamethasone, and immunotherapy can be stopped if necessary. When the rash symptoms are mild, follow the doctor’s instructions can be applied externally to relieve the symptoms, such as glycerine lotion, mometasone furoate, etc., can also take antihistamines, citicoline, cetirizine, can be effective in relieving the symptoms of the rash. Immunotherapy can be continued at this time. When the symptoms of the rash are severe, the medication needs to be stopped as prescribed by the doctor. On top of antihistamines, short-term glucocorticosteroids such as dexamethasone and methylprednisolone need to be given systematically. Patients need to follow the doctor’s instructions for medication treatment, do not unauthorized use of drugs.