Many patients with a thin endometrium ask, “Does a thin endometrium affect pregnancy? In fact, if we compare a fertilized egg to a seed of life, the endometrium is the soil that nurtures the seed. If the endometrium is not thick enough, it is like the soil is not fertile enough to provide sufficient conditions for the fertilized egg to be laid and to grow and develop, thus affecting a woman’s fertility. So, let’s learn more about the thickness of the endometrium today! The thickness of the endometrium varies from 5 to 10 mm, and varies at different times: about 9-10 mm in the proliferative phase, 5-6 mm in the secretory phase, and 8-10 mm in the menstrual phase. The thickness of the endometrium varies with the ovarian cycle, the endometrium is in the proliferative phase from the 5th day of the menstrual cycle, the endometrium thickens continuously until the 14th day of menstruation, it can thicken to 3-4mm; in the second half of the menstrual cycle, the endometrium is in the secretory phase, but still continues to thicken, until the onset of menstruation the endometrium can be up to 10mm thick. under normal circumstances, the thickness of the endometrium in women is 8 – 12mm, the minimum cannot be lower than 6mm. In general, the thickness of the endometrium is around 10 mm in the immediate post-pregnancy period. According to the doctor, the thickness of the endometrium that is conducive to conception is about 8 mm. The best period of endometrium for easy conception is during the luteal phase. The endometrium is thickened by endogenous estrogen (1) non-ovulation: in adolescent girls, perimenopausal women, hypothalamic-pituitary-ovarian axis disorders, polycystic ovary syndrome, etc., there can be non-ovulation, so that the endometrium is continuously affected by estrogen for a longer period of time, without progesterone counteracting, lacking the transformation of the cyclic secretion period, and in a proliferative state for a long time. endometrium under 40 years old In patients with atypical hyperplasia, except for focal atypical hyperplasia, more than 80% of the endometrium has no secretory phase; 70% of the basal body temperature measurements are monophasic. Therefore, most of the patients have no ovulation. (2) Obesity: In obese women, androstenedione secreted by the adrenal gland is converted into estrone by the action of aromatase in adipose tissue; the more adipose tissue there is, the stronger the conversion ability, and the higher the plasma level of estrone, thus causing persistent estrogenic effects. (3) Functional endocrine tumors: Functional endocrine tumors are rare tumors, but 7.5% of them are functional endocrine tumors in research statistics. The pituitary gland has abnormal gonadotropic function, and ovarian granulosa cell tumors are also tumors that continuously secrete estrogen. Exogenous estrogen (1) Estrogen replacement therapy (ERT): Perimenopausal or postmenopausal patients have menopausal syndrome due to estrogen deficiency, and may also have osteoporosis, abnormal lipid metabolism, cardiovascular changes, and even changes in brain cell activity. Therefore, ERT is gradually being widely used and has achieved very good results. However, ERT with estrogen alone can stimulate endometrial hyperplasia. The use of estrogen alone for one year can cause endometrial hyperplasia in 20% of women (Woodruff 1994), and the application of ERT is often continuous over the years, even until the end of life, for a long time. (2) Application of Tamoxifen: Tamoxifen (Tamoxifen TAM) has anti-estrogenic effect, so it is used in postmenopausal patients with advanced breast cancer. Under the condition of low estrogen, TAM has a weak estrogen-like effect, so long-term administration of TAM can also cause endometrial hyperplasia. Treatment of endometrial atypical hyperplasia should first be clearly diagnosed and the cause of the atypical hyperplasia should be found out, whether there are polycystic ovaries, functional ovarian tumors or other endocrine dysfunctions. Those with any of these conditions should be treated in a targeted manner. At the same time, symptomatic treatment of endometrial atypical hyperplasia can be started with either pharmacological or surgical treatment. The choice of these two treatment options should be based on age, type of endometrial hyperplasia, fertility requirements and other treatment options. The thickness of the endometrium varies at different times of a woman’s menstrual cycle, mainly due to the influence of hormone secretion at different times. If the thin endometrium is caused by factors such as miscarriage, it can have a great impact on a woman’s pregnancy. There are many reasons for endometrial thinning, the most common ones are: 1, endocrine disorder Women’s emotions have a great impact on the endometrium, long-term nervous and worried psychology often leads to endocrine disorder, which affects the thickness of the endometrium. 2, abortion scraping on the endometrium caused damage to the endometrium is divided into three layers, the uppermost layer is peeled off every month, the middle layer and the bottom layer is not peeled off, if the middle layer is damaged, the impact is not big, if the bottom layer is damaged, then the consequences will be more serious. 3, endometrial lesions such as endometrial polyps, endometrial cancer, etc. A thin endometrium can make it difficult for a fertilized egg to be laid, which can lead to infertility.