There is no relevant information on which specific 24 diseases Si Reverse San can treat. Si Reverse San has the efficacy of dispelling depressed heat, dredging the liver and regulating the spleen. It can be used to treat Yang depression and syncope (poor circulation of Yang qi leading to cold limbs), which is characterized by lack of warmth in the hands and feet, abdominal pain, or discharge and heaviness in the lower part of the body; it can also be used to treat Liver-Spleen disharmony (inability of liver and spleen to work harmoniously), which is characterized by distension and pain in the ribs and hypochondrium, and pain in the epigastrium (stomach). In this formula, Chai Hu is used to relieve the liver of depression (treating depression by unblocking the liver’s qi), and to expel evils through the liver, and is the principal medicine. White Peony (白芍) converges Yin, nourishes Blood and softens the Liver (nourishes Blood and softens the Liver) as the subject, which enables Chai Hu to ascend and disperse without depleting Yin and Blood. Hovenia dulcis regulates qi and resolves depression, relieves heat and breaks up knots, and matches with Paeonia lactiflora to regulate qi and blood to harmonize qi and blood. Glycyrrhiza glabra is used to harmonize all medicines (harmonize the medicinal properties of different Chinese medicines), benefit the spleen and harmonize the middle. The contraindications and adverse effects of Si-Rei San are not known. It is recommended to consult a healthcare professional if taking this medicine.