After years of research and clinical practice, it has been found that the treatment of femoral head necrosis with imaging-guided precision injections into the diseased femoral head, together with systemic triple oxygen intervention, is highly effective. Femoral head necrosis has always been a difficult problem for the global medical community, especially since the introduction of hormones and their widespread use, the incidence of this disease has gradually increased. Femoral head necrosis is caused by hormones, alcohol abuse and trauma, and is characterized by inflammation, edema, exudation, ischemia and necrosis of the femoral head, mainly manifesting as hip pain and limited movement, and can lead to disability if not treated in time. The most effective treatment is artificial joint replacement, and there is no definitive conservative treatment available. The combination of imaging and computer technology provides unprecedentedly superior conditions for high-quality minimally invasive interventions. With the guidance of these technologies, physicians can transform previous blind punctures into visualized and precise interventions, thus achieving maximum efficacy with minimal damage and side effects. More than 30 patients with osteonecrosis of the femoral head have been treated with this technology and have achieved satisfactory results. Mr. Wu from Liaoning province was 52 years old. Three years ago, after taking hormones for the treatment of rheumatoid, he had pain in his hip at night, and later the pain worsened and he developed a severe limp, and was found to have ischemic femoral head necrosis. He was diagnosed with the help of advanced imaging means such as MRI and CT 3D reconstruction technology. Based on the precise design of the interventional puncture path, he used ultrasound for timely guidance and precise drug delivery to the diseased femoral head to achieve anti-inflammatory and nutritional treatment. In view of the patient’s concurrent rheumatoid and other medical diseases, he simultaneously administered systemic triple oxygen intervention to the patient through autologous blood and rectum. After 2 consecutive months of treatment, the patient’s femoral head necrosis improved comprehensively, the rheumatoid factor turned negative, and the elevated blood sedimentation returned to normal for the first time in two years. Morning stiffness was greatly improved, and the tendon sheath cyst disappeared. The results were beyond the expectations of both doctors and patients. A year and a half later, MRI review revealed that the original bone marrow edema of Mr. Wu’s femoral head had disappeared, which is an important sign of newly discovered femoral head necrosis in recent years. Abnormalities in the systemic internal environment are also an important basis for the pathogenesis of localized lesions of the femoral head, because three of the four major causes of femoral head necrosis (hormone use, alcoholism and decompression sickness) are systemic factors, and the mechanisms of action of blood or rectal trioxides such as anti-inflammatory, immune boosting and metabolic promotion will undoubtedly contribute to the treatment of localized lesions of the femoral head. The clinical work of Jianxiong An’s research group has now demonstrated that systemic modulation therapy can significantly improve the durability of the efficacy of femoral head necrosis treatment.