The significance of renal puncture, i.e. renal puncture biopsy, is to clarify the pathological type of renal disease so as to better guide clinical treatment. The specific operation of renal puncture biopsy is to use color ultrasound and other localization to gradually puncture the puncture needle through the body surface to the renal lesion, remove a small amount of renal tissue, and then carry out pathological biopsy. Under the light microscope and electron microscope to observe the tissue structure of the kidney and the degree of lesions, to clarify the pathological changes of kidney disease, so as to guide the doctor to formulate a more suitable treatment plan for the patient, which is conducive to the recovery of the disease. Usually, renal puncture biopsy is an invasive test with certain risks, such as bleeding, infection, and arteriovenous endovascular fistula. Therefore, when a patient needs to undergo renal puncture biopsy, it must be performed by a professional doctor in a regular hospital to avoid unnecessary risks.