At present, the drug treatment after metastatic prostate cancer includes endocrine therapy, chemotherapy and so on. 1. Endocrine therapy: Abiraterone combined with prednisone is usually recommended for patients with metastatic prostate cancer who are sensitive to hormones. 2. Targeted therapy: for patients with bone metastasis of prostate, the commonly used drugs are mainly desutumumab, etc., which can control bone metastasis and reduce bone damage. 3. Radionuclide therapy: Radionuclides such as radium-223 or strontium-89 are usually applied, which can also control bone metastasis and reduce bone damage. 4. Treatment of bone damage in patients with bone metastases: bisphosphonate phosphate is to treat bone destruction, relieve bone pain, prevent and delay the occurrence of bone-related events. 5. Supportive treatment: for patients with combined pain, analgesic treatment can be carried out under the guidance of doctors. Overall, there are more drug treatment options for advanced prostate cancer, which need to be combined with the specific conditions of patients to choose the appropriate program. Please strictly follow the doctor’s instructions for drug treatment and do not use drugs on your own.