The late reaction of adenoid cystic carcinoma is mainly caused by the spread of cancer cells along the nerves, which results in facial palsy, distortion of the mouth and eyes, inability to puff up the mouth after closing it, loss of sensation in the tongue area, and severe pain in the lower part of the head. When the patient has this disease, the cancer will cause lesions in the neighboring organs, such as submandibular gland or sublingual gland, which will involve the mandible, and the cancer will also occur in the palate and other parts of the body, and will cause severe pain in the lower jaw and palate. Once the disease becomes advanced, there is no good medicine to treat the disease and chemotherapy is the only way to keep the patient alive.