High endogenous creatinine clearance may be caused by pregnancy, early diabetic nephropathy and so on; low endogenous creatinine clearance is caused by various kidney diseases.
Endogenous creatinine clearance is an indicator of renal filtration function, and its elevation is mainly seen in pregnancy, early diabetic nephropathy and so on. Glomerular hypertrophy in the early stage of diabetic nephropathy shows high filtration state, which should be treated in time.
Low endogenous creatinine clearance suggests a decrease in glomerular filtration rate, which is mainly caused by various renal diseases, the more common ones are chronic glomerulonephritis, nephrotic syndrome, lupus nephritis, hereditary nephropathy and so on.
High or low endogenous creatinine clearance should go to the hospital in time and be treated under the guidance of professional physicians.