Whether or not cephalosporin is effective for gastroenteritis depends on whether the gastroenteritis is caused by a bacterial infection or by other factors such as the use of certain medications or bile reflux. If the gastroenteritis is caused by a bacterial infection, cephalosporin is usually effective. If the gastroenteritis is caused by viral infection such as rotavirus, norovirus, then taking cephalosporin is not effective, if it is caused by bacterial infection such as E. coli, salmonella, then you can take cefixime and other drugs for treatment, it is recommended that under the guidance of the doctor to choose the causative organism is sensitive to the antibiotics for treatment. In addition, if the gastroenteritis is caused by taking aspirin, ibuprofen and other drugs, then you need to stop the drug immediately, and can take omeprazole and other drugs for treatment; if it is due to bile reflux caused by gastroenteritis, then you need to take domperidone, bismuth potassium citrate, magnesium aluminum carbonate and other drugs for treatment. Cephalosporin generally has no significant effect on these two kinds of gastroenteritis. Patients should seek timely medical attention, and drugs should be used under the guidance of a doctor.