The manifestations of pancreatic cancer in the middle and late stages are: 1. uncontrollable abdominal pain, the effect of general painkillers is poor, and painkillers such as morphine are needed; 2. severe malnutrition and significant wasting; 3. abdominal masses, hard masses can be palpated in the upper abdomen with poor mobility. Nodules can also be palpated in the umbilicus; 4, a large amount of ascites; 5, the performance of metastatic sites, lung metastases manifested as cough, hemoptysis, etc.