Smoking can lead to nicotine, nicotine and other harmful substances into the body, these substances can cause mucosal damage to the digestive tract, vascular constriction, the secretion of the pancreas and pancreatic blood supply have an impact on the pancreas, triggering the recurrence of pancreatitis. 1. Impact on pancreatic secretion: Nicotine and other substances can damage the mucous membrane of the gastrointestinal tract, resulting in gastrointestinal cells can not secrete sufficient amount of pancreatin to promote the secretion of pancreatic juice; mucous membrane damage will also make the gastrointestinal tract peripheral nerves to release a decrease in acetylcholine, affecting the vagus nerve to regulate pancreatic secretion. Obstructed pancreatic secretion may digest its own cells, leading to recurrence of pancreatitis. 2. Affect the blood supply of the pancreas: the blood supply of the pancreas is reduced, the pancreatic follicles are destroyed and a large amount of pancreatic enzymes are released, the pancreatic enzymes can digest their own tissues, causing local inflammation, leading to pancreatitis. Although smoking is not a common cause of pancreatitis, it may still induce pancreatitis. Therefore, it is recommended that long-term smokers and those who have been cured of pancreatitis quit smoking as much as possible to minimize the damage to the pancreas and reduce the incidence of pancreatitis.