For inverted nipple with clear etiology, the first thing to do is to actively treat the primary disease, after the primary disease is treated, the symptom may be relieved; if it is not relieved after the primary disease is treated, the symptom may be relieved by manipulation and pulling, suction therapy or surgical treatment. 1. Treatment of primary disease, such as mastitis, can be treated by applying penicillin, erythromycin, metronidazole and other drugs, or by laser perforation and other surgical methods; breast cancer and other causes, it is necessary to be treated by surgery, radiotherapy, endocrine therapy, targeted therapy and other ways of treatment depending on the situation, the specific treatment should be followed by the doctor’s advice to choose. 2. If the original disease is not relieved after treatment, the following methods can be used as appropriate. (1) Manipulation: When nipple inversion occurs in adolescent patients, the nipple should be pulled appropriately, which can make the nipple protrude. This method needs to be performed gradually and continuously, and the treatment effect is relatively good. (2) Suction therapy: patients with inverted nipple can also use negative pressure suction device to pull on the inverted nipple, which can also lengthen the mammary ducts as well as the fibrous strips to improve the symptoms of inverted nipple. (3) Surgical treatment: If the results of the above methods are poor, patients can also be treated with surgery to preserve the milk ducts. Women who do not want to breastfeed can take the surgery of cutting off the milk ducts, and the prognosis is better. Patients with inverted nipple should consult the doctor in time and take the appropriate treatment.