Pantoprazole sodium enteric-coated tablets and omeprazole both belong to the proton pump inhibitors, with strong inhibition of gastric acid secretion, these two drugs can not be taken at the same time. 1. Pantoprazole sodium is a proton pump inhibitor. Clinically, it is mainly used for the treatment of gastric ulcer, duodenal ulcer and moderate and severe reflux esophagitis and other diseases. Adverse reactions include diarrhea, nausea, epigastric pain, abdominal distension, rash, itching, dizziness, and visual disturbances. 2. Omeprazole, on the other hand, is a first-generation proton pump inhibitor, the main effect of which is to inhibit gastric acid secretion, and is commonly used in the treatment of peptic ulcer. Common adverse effects of omeprazole include nausea, vomiting, diarrhea, rash and headache. To summarize, the above two drugs have the same pharmacological effects and superimposed side effects, and taking them at the same time belongs to the duplication of medication, which will increase the side effects. Therefore, these two drugs should not be taken at the same time. In the process of taking proton pump inhibitor drugs, once the rash, diarrhea and headache appear, you need to stop the drug instantly, and consult a doctor in time if the symptoms are not relieved.