The reporter heard a strange story from the professor: a patient who had three pregnancies and three fetal deaths, from obstetrics and gynecology to hematology, finally found the cause of the disease in the rheumatology and immunology department and treated it! Not long ago, the patient Xiao Li (a pseudonym) came to the hospital for a review, and the results showed that the test indicators had been normal. She couldn’t contain her excitement and eagerly asked the attending doctor, “Can I get pregnant now?” “Of course you can!” . ”Of course you can.” This ordinary sentence was the same as lifting a curse for Xiao Li – the curse of three pregnancies and three fetal deaths that nearly killed her! The nightmare: three pregnancies all fetal death Xiao Li, who lives in the suburbs of Beijing, got pregnant soon after her marriage at the age of 21. However, when she was three months pregnant, she found out during a medical checkup at a nearby hospital that the baby in her belly had no heartbeat! As a result, she had to undergo an abortion. Pre-operative blood tests revealed that her platelets were very low, at a level of 60,000-70,000, when the normal value should be (100,000-300,000). After the hospital gave her an emergency platelet transfusion, the surgery was done successfully. After the surgery, the doctor advised her to rush to the internal medicine department, but she didn’t go. A year later, Xiaoli got pregnant for the second time, and by the fourth or fifth month, the examination revealed that the baby had a heart problem! And Xiaoli’s platelet level dropped to a very low level again. She was treated with platelet transfusions again and had another miscarriage. But this time it still did not attract the family’s attention. Some time later, Xiao Li became pregnant for the third time. At four or five months, her body showed many abnormalities: many bleeding spots appeared on her skin, and her gums were bleeding frequently. One day, she suddenly fainted and an emergency examination at the hospital revealed that her platelet level was as low as less than 20,000! She was transferred to the hematology department for resuscitation and her life was temporarily out of danger. When the baby grew to 6-7 months in the womb, a gynecological examination revealed that the fetus had no fetal heartbeat again! At this point, the failure to be a mother was secondary to the fact that Xiao Li’s platelet level had dropped again and her life was in danger. The fetus in her belly was already very large, and her platelet level was so low that the doctor did not dare to induce labor. She was urgently transferred to the Department of Obstetrics and Gynecology of Peking University First Hospital. After understanding her condition, doctors suspected that she was suffering from autoimmune disease and hurriedly transferred her to the Department of Rheumatology and Immunology. In the Department of Rheumatology and Immunology, she was diagnosed with lupus erythematosus secondary to antiphospholipid syndrome. The rheumatology department immediately gave Xiao Li medication, and soon her platelets rose and bleeding stopped, and the obstetrics and gynecology department successfully helped the patient to complete the induction of labor. The fetus in the womb was starved to death, said Zhang Zhuoli, adding that antiphospholipid syndrome is an autoimmune disease. The antiphospholipid antibodies in the patient’s body are too high to form blood clots. When the thrombus appears in the legs, the legs are swollen; if it appears in the small blood vessels of the placenta, the small blood vessels of the placenta will be blocked, which is the same as cutting off the channel to provide nutrients to the fetus, eventually leading to miscarriage or fetal death. This is the reason why Xiao Li’s three pregnancies were stillborn. Reviewing her medical history, Zhang Zhuoli speculated that Xiao Li probably had early lupus erythematosus since she was 15 years old, when she had seen a hematologist because her gums often bled when she brushed her teeth. Laboratory tests revealed low platelets and bone marrow tests showed low bone marrow megakaryocytes. The doctor diagnosed her with idiopathic thrombocytopenic violet epilepsy and recommended that she receive medication. However, because her condition was not particularly serious and had little impact on her life, and because of her family’s limited financial situation, she did not pay much attention to it and did not insist on taking medication. As a result, the condition was left unattended for a long time until it finally broke out when she got pregnant after marriage.