Developing resistance to fusidic acid cream suggests changing the treatment to another antibiotic class. Fusidic acid cream is a dermatologic antibiotic that is used to treat skin infections caused by staphylococcus, streptococcus, and Propionibacterium acnes. If you develop resistance to fusidic acid cream, it is recommended that you switch to other antibiotic medications, such as erythromycin ointment, mupirocin ointment, and lincomycin cream for anti-infective treatment. When skin infections occur, it is recommended to go to the hospital for a checkup to identify the pathogen and follow the doctor’s instructions according to the degree of infection, to avoid self-medication, which may cause drug resistance or serious adverse reactions.