ABO hemolysis may occur after pregnancy when the woman is type O and the man is type AB, but it is not absolute. If the woman has type O blood and the man has type AB blood, the mother’s type O blood contains anti-A antibody and anti-B antibody, and the child born to the man with type AB blood can have type A or type B blood, which will combine with anti-A antibody and anti-B antibody and cause destruction of red blood cells, and there will be hemolysis in newborns, but it is not absolute. Hemolysis testing, such as IgG antibody potency testing, is usually performed during pregnancy, and interventions during pregnancy and prior to delivery can reduce the incidence of hemolysis. A baby born to a woman with blood type O and a man with blood type AB with ABO hemolysis may present with progressively worsening yellow staining after birth, anemia, and in severe cases, enlarged liver. During pregnancy due to blood type problems increase the chances of newborn ABO hemolysis, pregnancy is more important to do a good job of maternity testing, there are abnormalities in time to deal with.