Anal pain after sitting for a long time is mainly related to hemorrhoids, perianal abscesses, perianal boils and other causes. 1. Hemorrhoids: the veins at the anus and rectum are dilated, tortuous, and form clusters of veins, the most common anorectal disease, due to prolonged sitting, squeezing hemorrhoids, producing pain. It can be treated with topical ointments or suppositories, such as hydrocortisone ointment, musk hemorrhoid cream, anus tylenol suppositories and so on. Follow the doctor’s instructions to use. 2. Perianal abscess: due to the infection in the rectal and anal canal tissues or their surrounding interstitial space, causing perianal pain, resulting in prolonged sitting and pressure on the perianal area, producing pain. It can be relieved or controlled by oral amoxicillin capsules, aspirin tablets, ibuprofen extended-release capsules, etc. Surgery is required for severe cases. 3. Perianal boils: due to purulent inflammation of the deep perianal follicles and surrounding tissues, prolonged sitting will stimulate the wound and produce pain. It can be treated by local topical medication, such as ichthyol ointment, tincture of iodine, mupirocin ointment and so on. Sitting for a long time anal pain may also be related to other diseases, it is recommended to go to the regular hospital, clear cause of the cause under the guidance of a professional doctor to carry out further examination and treatment.