Paroxetine, generic name is polyethylene glycol interferon alpha-2a injection; Pegabine, generic name is polyethylene glycol interferon alpha-2b injection, both are medications for the treatment of hepatitis B or C, and should not be used in combination. Polyethylene glycol interferon alpha-2a injection is indicated for chronic hepatitis B. Common adverse reactions include nosebleeds, rhinitis, sore throat mouth ulcers, and muscle spasms, etc. It is contraindicated in patients with a history of severe heart disease and autoimmune chronic hepatitis. Polyethylene glycol interferon alpha-2b injection is suitable for chronic hepatitis B and chronic hepatitis, common adverse reactions include dry mouth, abdominal pain, vomiting, chest pain and mood changes, etc. It is contraindicated in patients with autoimmune chronic hepatitis and severe liver dysfunction. The pharmacological effects of the above two drugs are similar to those of interferon, and their combined use may lead to excessive efficacy and affect the health of the body, which may result in adverse effects; in addition, the application of the above drugs carries a certain degree of risk, and patients need to be under the guidance of a specialized doctor to apply them.